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Ampoule Filling Line

The ampoule filling line consists of a ACX Rotary Washing machine, SZA strerilisation tunnel and AGF Filling and Sealing Machine. Tofflon Filling Solutions offers cutting-edge technology compliant with FDA and GMP standards, ensuring safety and efficiency in pharmaceutical production.

Advanced Aseptic Processing Design

Advanced Aseptic Processing Design emphasises minimal human contamination in critical processes through systems integration with upstream tunnels and downstream equipment. This ensures a highly integrated, safely interlocked, and reliably recorded aseptic processing line, with a focus on RABS integration by design. It incorporates good practices in high-speed, large-scale, high-efficiency injectable manufacturing, reducing operator needs and operating costs. The servo motor control system ensures high automation, operational accuracy, and process reproducibility. Production batch reports are automatically generated, complying with GAMP5 and 21CFR PART 11, alongside critical parameter monitoring with record, print, and backup options. Additionally, fewer change parts and a tool-less design allow for quick changeovers.

Industry leading delivery times

Tofflons efficient manufacturing assures an industry leading delivery time for its products.


Yan Shen

Project Manager

“We will work with your team to choose the best products and specifications for your requirements. We can handle everything from the first phone call to installation.”

Call: + 33 6 31 55 95 79

Ampoule Filling & Sealing Machines

The Tofflon AGF Filling and Sealing Machine offers advanced features for optimal performance, including ceramic or stainless steel piston pump filling options. Driven by a precise servo motor, it incorporates nitrogen gas flushing before and after filling to ensure product integrity. Additionally, the machine is safeguarded by LAF and RABS protection systems, enhancing both safety and reliability.

Ampoule Specification1ml-20ml1ml-20ml1ml-20ml1ml-10ml1ml-20ml1ml-10ml
Product Speed260 apm (2ml)360 apm (2ml)400 apm (2ml)500 apm (2ml)500 apm (2ml)600 apm (2ml)
Filling Accuracy+/- 1%+/- 1%+/- 1%+/- 1%+/- 1%+/- 1%
Broken Rate≤0.1%≤0.1%≤0.1%≤0.1%≤0.1%≤0.1%
Qualified Rate≥99%≥99%≥99%≥99%≥99%≥99%
0.05Mpa Gas Consumption0.3m3/h0.35m3/h0.4m3/h0.5m3/h0.5m3/h0.8m3/h
0.4Mpa Oxygen Conspumtiom≤0.75m3/h≤1m3/h≤1.2m3/h≤1.5m3/h≤1.5m3/h≤1.5m3/h
Dimensions (LxWXH) mm3400x1600x26003400x1600x26003400x1600x26003400x1600x26004070x1710x26004070x1710x2600

SZA Sterilisation Tunnel

Tofflon Ampoule Filling Line, designed for the precise filling of ampoules in pharmaceutical production, showcasing streamlined efficiency and advanced technology for high-quality drug packaging

The Tofflon SZA Sterilization Tunnel is engineered for high performance and safety. It features negative pressure sealing for HEPA filters, and its interior is made of stainless steel to mitigate the risk of oxidation. Advanced functions like automatic air balance and door position control, which can be set to manual or automatic, further enhance its operational efficiency and reliability.

Ampoule Specification1ml-20ml1ml-20ml
Belt Width600mm600mm
Product Speed750 apm (2ml)750 apm (2ml)
Broken Rate≤0.2%≤0.2%
Qualified Rate≥99.9%≥99.8%
Cooling TypeAir Cooling: Room TemperatureAir Cooling: Room Temperature
Air Consumptiom3,000-3,500m3/h1,000-1,300m3/h
Water ConsumptionN/A0.6-0.9 m3/h
Weight3,500 Kg3,500 Kg
Dimensions (LxWxH) mm4400x1550x23004400x1550x2300

Washing Mashine

A Tofflon Ampoule Filling Line, a precision-engineered pharmaceutical machine with a clear protective enclosure and internal mechanisms on display, equipped with a control panel and status indicator lights, designed for the sterile and efficient filling of ampoules

The Tofflon ACX Rotary Washing Machine offers a compact yet flexible layout tailored for high-efficiency operations. It features an in-feed conveyor with a double design to prevent cross-contamination, ultrasonic washing, and alternant washing capabilities using water and compressed air. The machine’s gripper turns in situ, eliminating forwards-backward movement. Constructed with a hard aluminum-alloy big rotary drum and an integrated internal gear, the design enhances both reliability and precision. The machine is driven by a service motor for optimal performance.

Ampoule Specifications1ml-20ml1ml-20ml1ml-20ml1ml-20ml1ml-10ml
Product Speed300 apm (2ml)400 apm (2ml)500 apm (2ml)600 apm (2ml)700 apm (2ml)
Broken Rate≤0.2%≤0.2%≤0.2%≤0.2%≤0.2%
Qualified Rate≥99.9%≥99.9%≥99.9%≥99.9%≥99.9%
Compressed Air0.4-0.6Mpa0.4-0.6Mpa0.4-0.6Mpa0.4-0.6Mpa0.4-0.6Mpa
Air Consumption30m3/h35m3/h40m3/h50m3/h60m3/h
WFI Pressure0.3-0.4Mpa0.3-0.4Mpa0.3-0.4Mpa0.3-0.4Mpa0.3-0.4Mpa
WFI Consumption0.3 m3/h0.35 m3/h0.4 m3/h0.5 m3/h0.6 m3/h
Vapor Exhaust200m3/h250m3/h300m3/h350m3/h400m3/h
Weight2,500 Kg2,500 Kg3,000 Kg3,000 Kg3,000 Kg
Dimensions (LxWxH) mm2330x2330x13602330x2330x13602330x2330x13602330x2330x13602330x2330x1360

Service through product lifetime

We provide services at all stages in the lifetime of the equipment, keeping the equipment in good working order and prolonging the lifetime of the installations.

Over 40 years experience

Founded in 1976, Sofinn Group of companies provides a comprehensive range of state of the art equipment for the pharmaceutical and biotech industries. We provide turnkey solutions for destillation, sterilisation, lyophilisation, decontamination, washing and filling. accusantium doloremque laudantium.

Experts in pharmaceutical solutions products

As your trusted partner in service and equipment solutions, we are deeply committed to quality, specialising in sterilising water and pharmaceutical equipment.

Specialised in Quality: Focused on sterilising water and pharmaceutical equipment.

Customer-Centric: Your satisfaction drives our exceptional service.

Project Simplification: Making even the most complex tasks manageable.

Timely Delivery: Get what you need, when you need it.

Tailored Solutions: Match your project with the most effective technology.

Industrial Purified Water Reverse Osmosis (RO) and Continuous Electrodeionization (CEDI) Unit, showcasing a complex assembly of pipes, tanks, and filtration systems mounted on a skid with a blue control panel on the right side. The unit features an array of stainless steel components and a digital control interface designed for automatic function, surveillance, and maximum operational safety. Suitable for high-quality water purification processes, offering flexible operation with hot water sanitation capabilities and easy installation, with a capacity range from 200 to 7,000 liters per hour.
Compact industrial water purification system with a vertical silver tank labelled 'AQUA-NOVA,' attached to a grey control cabinet with multiple control buttons and indicators. Adjacent is a larger blue control panel with digital displays and readouts for monitoring and adjusting the system's performance. Designed for efficiency and reliability in water treatment processes, the system appears to be ready for high-purity applications, featuring a modular construction for easy maintenance and operation.

Specialist in pure, clean and sterile applications

Tel: + 44 1633 415 355 
Email : [email protected]

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